beta lactam side chain chart|Northwestern Medicine : Clark The NM beta-lactam cross-reactivity side chain chart is a guide and should be used with the NM beta-lactam Allergy Risk Assessment and Clinical Pathway for Outpatients or Non-Critically Ill Inpatients when assessing the decision to drug challenge with a beta-lactam. Universal Time Coordinated is 8 hours behind PST () and 8 hours behind Philippine Time. 3:00 am in UTC is 11:00 am in Conversion, Philippines and is 11:00 am in PHT. UTC to Conversion call time.
beta lactam side chain chart,
• The R1 side chain is the major factor for cross-reactivity due to antibody recognition between cephalosporins and penicillins. • Cross-reactivity with cefazolin or carbapenems is very unlikely
The NM beta-lactam cross-reactivity side chain chart is a guide and should be used with the NM beta-lactam Allergy Risk Assessment and Clinical Pathway for Outpatients or Non-Critically Ill Inpatients when assessing the decision to drug challenge with a beta-lactam.
Select a b-lactam with a dissimilar R1/R2 side chain (clear box) • The R1 side chain is the major factor for cross-reactivity due to antibody recognition between cephalosporins and penicillins. X Cbeta lactam side chain chart beta-lactam antibiotics if the reported reactions are “itching,” “rash,” and/or “unknown.” The chart below is a reference for which beta-lactams share similar side chains. This may be used to guide clinical decisions surrounding which antibiotics are appropriate to use in patients with specific beta-lactam allergies. AMSSC 11/16/2022
The β-lactam ring in penicillins is connected to a five-membered thiazolidine ring, or penam, and the side chain, R, differentiates the different penicillins. In cephalosporins, the β-lactam ring is bonded to a six-membered dihydrothiazine ring, or cepham [ 46 , 71 ].Same side chain - clinical evidence of cross reaction. AVOID Same side chain - Theoretical risk of cross reaction, no clinical studies. AVOID Similar side chain - Potential for cross reaction. USE WITH CAUTION: Monitor first dose closely (vital signs at 15, 30, and 60 minutes post-first dose)
Matrix of β-Lactam Side Chain Similarities; The chart is read from left to right and top to bottom. Select an agent from the left column and an agent from the top row. To determine side chain similarities, find intersecting box & interpret per below criteria: Blank Spaces: Indicate the absence of similar side chains. Risk of cross-reactivity is
Northwestern Medicine Matrix of β-Lactam Side Chain Similarities; The chart is read from left to right and top to bottom. Select an agent from the left column and an agent from the top row. To determine side chain similarities, find intersecting box & interpret per below criteria: Blank Spaces: Indicate the absence of similar side chains. Risk of cross-reactivity isbeta lactam side chain chart Northwestern Medicine Matrix of β-Lactam Side Chain Similarities; The chart is read from left to right and top to bottom. Select an agent from the left column and an agent from the top row. To determine side chain similarities, find intersecting box & interpret per below criteria: Blank Spaces: Indicate the absence of similar side chains. Risk of cross-reactivity is
This chart describes the risk of cross-reactivity between 2 beta-lactams antibiotics. Shaded boxes indicate either a similar (gray) or an identical (red) side chain, and therefore higher risk for an allergic reaction.
beta lactam side chain chart|Northwestern Medicine
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